| 2022-09-03 15:00:003rd September 2022 |   Birmingham Moseley vs Sale FC | 13 - 32 | National One | 2022-2023 | | Recap |
| 2022-09-10 14:30:0010th September 2022 |  Sale FC vs Leeds Tykes | 56 - 8 | National One | 2022-2023 | | Recap |
| 2022-09-17 15:00:0017th September 2022 |  Plymouth Albion vs Sale FC | 24 - 27 | National One | 2022-2023 | | Recap |
| 2022-09-24 14:30:0024th September 2022 |  Sale FC vs Taunton Titans | 31 - 24 | National One | 2022-2023 | | Recap |
| 2022-10-01 15:00:001st October 2022 |  Cambridge vs Sale FC | 32 - 19 | National One | 2022-2023 | | Recap |
| 2022-10-15 15:00:0015th October 2022 |  Cinderford vs Sale FC | 27 - 26 | National One | 2022-2023 | | Recap |
| 2022-10-22 14:30:0022nd October 2022 |  Sale FC vs Esher | 35 - 21 | National One | 2022-2023 | | Recap |
| 2022-10-29 15:00:0029th October 2022 |  Chinnor vs Sale FC | 18 - 37 | National One | 2022-2023 | | Recap |
| 2022-11-05 14:30:005th November 2022 |  Sale FC vs Hull RUFC | 34 - 7 | National One | 2022-2023 | | Recap |
| 2022-11-12 15:00:0012th November 2022 |  Bishop's Stortford vs Sale FC | 22 - 29 | National One | 2022-2023 | | Recap |
| 2022-11-26 14:30:0026th November 2022 |  Sale FC vs Darlington Mowden Park | 34 - 31 | National One | 2022-2023 | | Recap |
| 2022-12-03 15:00:003rd December 2022 |  Rams vs Sale FC | 24 - 27 | National One | 2022-2023 | | Recap |
| 2022-12-10 14:00:0010th December 2022 |  Sale FC vs Rosslyn Park | 24 - 15 | National One | 2022-2023 | | Recap |
| 2022-12-17 14:00:0017th December 2022 | Leeds Tykes vs Sale FC | 15 - 20 | National One | 2022-2023 | | Recap |
| 2023-01-07 14:30:007th January 2023 | Sale FC vs Plymouth Albion | 45 - 35 | National One | 2022-2023 | | Recap |
| 2023-01-14 15:00:0014th January 2023 | Taunton Titans vs Sale FC | 14 - 19 | National One | 2022-2023 | | Recap |
| 2023-01-21 14:30:0021st January 2023 | Sale FC vs Cambridge | 19 - 35 | National One | 2022-2023 | | Recap |
| 2023-01-28 14:30:0028th January 2023 | Sale FC vs Cinderford | 24 - 17 | National One | 2022-2023 | | Recap |
| 2023-02-18 15:00:0018th February 2023 | Esher vs Sale FC | 27 - 54 | National One | 2022-2023 | | Recap |
| 2023-02-25 14:30:0025th February 2023 | Sale FC vs Chinnor | 27 - 17 | National One | 2022-2023 | | Recap |
| 2023-03-04 15:00:004th March 2023 | Hull RUFC vs Sale FC | 12 - 19 | National One | 2022-2023 | | Recap |
| 2023-03-11 14:30:0011th March 2023 | Sale FC vs Bishop's Stortford | 31 - 7 | National One | 2022-2023 | | Recap |
| 2023-03-25 15:00:0025th March 2023 | Darlington Mowden Park vs Sale FC | 10 - 35 | National One | 2022-2023 | | Recap |
| 2023-04-01 14:30:001st April 2023 | Sale FC vs Rams | 35 - 12 | National One | 2022-2023 | | Recap |
| 2023-04-15 15:00:0015th April 2023 | Rosslyn Park vs Sale FC | 19 - 33 | National One | 2022-2023 | | Recap |
| 2023-04-22 15:00:0022nd April 2023 | Sale FC vs Birmingham Moseley | 15:00:0015:00 | National One | 2022-2023 | | Recap |
